Pulsatile drug delivery system is most important now a day as it release the drug in a planned pattern at specific time as per the pathophysiological need of the disease resulting in improved patient compliance and therapeutic efficacy. This system is designed for chronopharmacotherapy, which is based on circadian rhythm. The basic principle for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not preferred. Ideally, with a pulsatile system, the drug is released rapidly and transient after a defined lag time of no drug release. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. Different approaches are designed based on capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes, pH-sensitivity, time-dependency (lag time), etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes. Our aim in this review is to outline the rational and prominent design strategies behind site-specific oral pulsatile delivery. Marketed product like Pulsicap®, Cardizem® and Pulsys® are based on pulsatile release system.
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